Thursday, 02 Jul 2020

Botox may have long-lasting anti-aging effects, study suggests


Botox may have long-lasting anti-aging effects, study suggestsBotox may have long-lasting anti-aging effects, study suggests - Botox, long mocked for simply hiding wrinkles by partially paralyzing the face, may actually make skin more elastic and more resistant to wrinkles.

Botox, an injection that paralyzes facial muscles to reduce the appearance of wrinkles, has a reputation for being the remedy of choice for starlets because it’s superficial and fleeting.

But a recent study suggests it may not be quite as superficial or as temporary.

It turns out that the drug increases skin elasticity for three to four months, during which it remains active, according to a Canadian study published in the JAMA Facial Plastic Surgery by a dermatologist Dr. James Bonaparte of the University of Ottawa.

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The initial theory for Botox was you paralyze the muscle, you can’t make the wrinkle anymore because you can’t move.
Dermatologists had observed that even deep wrinkles that weren’t erased by Botox became less severe while it was active. Bonaparte has endeavored to measure the effect scientifically.

In the current study, he and and Dr. David Ellis of the University of Toronto used a Cutometer, a device that sucks the skin and measures how much it recovers to its previous position. As we age, our skin becomes less elastic, went down about 30% less at age 70 than it does at age 20.

Flaccid skin makes us look older. It also makes the skin more prone to wrinkle.

The researchers found that when the effects of Botox were at their most powerful, the drug could increase elasticity by 30%. The effect peaked at two months and then waned before dropping off at four months.

The researchers tracked 43 women who were using Botox for the first time.

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Bonaparte’s earlier work on the same topic was met with criticism. Critics argued that what seemed to be elasticity could simply be swelling as a result of the injury from injection. As the skin heals from injury it draws in more water and becomes more elastic for a week or two.

The current study ruled that out by showing that injury resulted in a different pattern of resistance to the suction.

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“Botox might be doing two things, one to the muscle one to the skin”, - Bonaparte said.

If indeed Botox makes the skin more elastic, it may also help prevent the formation of wrinkles. That could significantly expand the market for cosmetic injections.

Only Botox has the approval of the Food and Drug Administration for use on crow’s feet, but the others are often used off-label.

To nail down exactly how the botulinum toxins ramp up elasticity, the next step will be to remove small bits of skin from participants before and after the procedures.




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